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Although the V3 region of SIVmac can determine cell tropism 28none of these sequence changes that affect high replicative capacity to SIVmac in tissue macrophages reside in V3. Supporting these results, entry of SIVmac into macrophages was found to be similar to that of derivatives with these sequence changes However, the mechanisms which restrict SIVmac replication in tissue macrophages and allow sequence variants to replicate vigorously remain to be elucidated. We feel somehow that any attempt will squander, although we do wish to date and sleep with women.

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